United Kingdom (UK)
Recombinant monoclonal antibody to IL-3Ra. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 57A07.
UniProt Accession Number of Target Protein: P26951
Alternative Name(s) of Target: CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra; interleukin 3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha
Specificity: This antibody is specific for the alpha subunit of IL-3R
Application Notes: The binding of the original version of this antibody (VHH) to IL3-Ra-expressing viral lipoparticles was characterized in an ELISA (KD 0.783 nM). In a FACS binding assay, this antibody exhibited an EC50 of 0.66 nM, 1.3 nM, and 0.24 nM for MOLM-13, THP-1, and HEK-IL-R3a, respectively, and an IC50 of 1.20 nM in competition against clone 7G3. In its bi-specific constructions with clones 14D09 and 281F12, it served as an anchor (US20220242958).
Antibody first published in: PMID: Note on publication: The original publication describes the construction and characterization of various bi-specific antibodies.