United Kingdom (UK)
Recombinant monoclonal antibody to IL12RB1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 148C09.
UniProt Accession Number of Target Protein: P42701
Alternative Name(s) of Target: CD212; IL12RB1#30; IL-12R-beta-1; IL-12RB1; Interleukin-12 receptor subunit beta-1; L-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12 receptor beta component
Specificity: This antibody is specific for human IL12RB1
Application Notes: The binding of the original version of this antibody (VHH) to IL12RB1 was characterized in an SPR (KD 3.3 nM), ELISA (IC50 3.7 and 1.5 nM for IL-12 and IL-23, respectively), and FACS (EC50 1.3 nM). In its bi-specific constructs with Ab04387 (Anti-CD4 [3F11]), it served a functional role (US20220242958).
Antibody first published in: PMID: Note on publication: The original publication describes the construction and characterization of various bi-specific antibodies.