Anti-Indolicidin [V2D2 ]

Description:

Recombinant monoclonal antibody to Indolicidin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma V2D2 .

Clone Name:

V2D2

Published Application(s):

Block, ELISA

Published Species Reactivity:

Cow

Products based on this clone:

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Ab03998-1.1 Anti-Indolicidin [V2D2 ]
Cow
Mouse IgG1
Purified
Ships in 5-6 weeks

Ab03998-23.0 Anti-Indolicidin [V2D2 ]
Cow
Rabbit IgG
Purified
Ships in 5-6 weeks

UniProt Accession Number of Target Protein: P33046

Alternative Name(s) of Target: CATHL4; Cathelicidin-4; Antimicrobial peptide; antibiotic
Immunogen: The original antibody was generated by immunizing 8–10-week-old BALB/c mice with indolicidin conjugated to diphtheria toxoid.

Specificity: This antibody binds indolicidin (ILPWKWPWWPWRR), which is a potent antimicrobial peptide isolated from the neutrophil blood cells of cow. Indolicidin is a tryptophan-rich cationic broad spectrum antibiotic that can neutralize bacterial lipopolysaccharides and has immunomodulatory effects. Its antibacterial activity is realized inside the phagolysosomes of host neutrophils, outside of which it exhibits cytotoxicity. Some reports have demonstrated its interaction with various molecules like DNA, topoisomerase I, calmodulin, and ATP.

Application Notes: The binding characterization of this antibody was done using ELISA. It was reported that this antibody could bind indolicidin with a binding affinity of KD = 56 nM and could block the antibacterial action of the peptide (PMID: 20837490).

Antibody first published in: Lomash et al. An antibody as surrogate receptor reveals determinants of activity of an innate immune peptide antibiotic. J Biol Chem. 2010 Nov 12;285(46):35750-8. PMID:20837490
Note on publication: Describes the generation of this antibody as a surrogate receptor for indolicidin to identify a motif that contained almost the entire antibiotic activity of native indolicidin.

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