Anti-Insulin receptor [BBBB138]

Name: Anti-Insulin receptor [BBBB138]
SKU: Ab03960
Availability: InStock

Description:

Recombinant monoclonal antibody to Insulin receptor. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody BBBB138.

Clone Name:

BBBB138

Published Application(s):

in vitro, in vivo, SPR, ELISA

Published Species Reactivity:

Human

Product based on this clone:

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Ab03960-23.0 Anti-Insulin receptor [BBBB138]
Human
Rabbit IgG
Purified
In Stock

UniProt Accession Number of Target Protein: P06213

Alternative Name(s) of Target: IR
Immunogen: The original antibody was isolated from a human phage display library by panning against IR.

Specificity: The antibody is specific for the insulin receptor. The antibody recognises both short isoform (IR-A) and a long isoform (IR-B). The epitope of the antibody does not overlap with the insulin binding site.

Application Notes: The specificity of the antibody for IR was determined by ELISA analysis. The binding affinity of the antibody to IR-A and IR-B was measured by surface plasmon resonance (Kd= 2.57 and 2.98 nM respectively). The antibody blocked insulin induced IR phosphorylation in a dose-dependent manner on HuH7 cells. The antibody effectively decreased insulin induced glucose uptake at concentrations of 1 nM and 10 nM in vitro. The antibody induced hyperglycemia in C57 mice in in vivo experiments.

Antibody first published in: PMID:

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