Anti-Integrin alpha-1 [AQC2]

Description:

Recombinant monoclonal antibody to Integrin alpha-1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma AQC2.

Clone Name:

AQC2

Published Application(s):

crystallography, in vivo, WB, ELISA

Published Species Reactivity:

Sheep, Human

UniProt Accession Number of Target Protein: P56199

Alternative Name(s) of Target: hAQC2; huAQC2; VLA-1; CD49a; ITGA1; Laminin and collagen receptor; CD49 antigen-like family member A
Immunogen: The original antibody was raised by immunizing a mouse with human VLA-1.

Specificity: This antibody is specific for VLA-1

Application Notes: The structure of the humanized version of this antibody was determined using x-ray crystallography. The humanized antibody was used for an ELISA on human alpha 1 beta 1 I domain (Karpusas et al., 2003; PMID:12662928). This antibody was used for a western blot on alpha-1 integrin of different animals, showing that this antibody could also bind sheep alpha-1 integrin. This antibody was used as an aerosol to prevent allergic reactions in the lungs of sheep. It only showed an effect on the late airway responses and no effect on the initial allergic reaction (Abraham et al., 2004; PMID:14578216).

Antibody first published in: Gotwals et al. Divalent Cations Stabilize the alpha-1 Beta-1 Integrin I Domain Biochemistry. 1999 Jun 29;38(26):8280-8. PMID:10387073
Note on publication: The original paper generated and characterized a panel of antibodies directed against the alpha-1 I domain.

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