Anti-Junin virus Nucleoprotein [J1.2]

Description:

Recombinant monoclonal antibody to Junin virus Nucleoprotein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display clone J1.2.

Clone Name:

J1.2

Published Application(s):

ELISA, IF

Published Species Reactivity:

Junin mammarenavirus (JUNV)

UniProt Accession Number of Target Protein: Q6UY72

Alternative Name(s) of Target: N; JUNV protein N; JUNV nucleoprotein; JUNV nucleocapsid protein; JUNV protein N; nucleoprotein; nucleocapsid protein; protein N; Argentinian mammarenavirus; 1.2; Candid#1
Immunogen: The original antibody was isolated from a phage display library generated by immunizing an Alpaca with purified UV-inactivated Candid#1 virions and panning against Candid#1. Candid#1 is a live attenuated JUNV vaccine.

Specificity: This antibody binds the nucleoprotein of Junin virus (JUNV). Junin virus also known as Argentinian mammarenavirus is an arenavirus in the Mammarenavirus genus which causes Argentine Haemorrhagic Fever (AHF). Mammarenaviruses sporadically cause zoonotic infections in humans, which may lead to life-threatening viral haemorrhagic fever (VHF) disease. VHFs caused by arenaviruses are acute diseases with considerable mortality rates. Symptoms are fever, malaise, headache, nausea, diarrhea, petechial hemorrhage of the soft tissues, lethargy, and irritability. Members of the Arenaviridae family are enveloped viruses with a bi-partite RNA genome coding for four viral proteins. The virus is spread through the aerosolization of host rodent excreta.

Application Notes: This antibody is capable of binding to Candid#1 infected Vero cells. The binding to infected Vero cells was evaluated by ELISA. It was reported that this antibody can prevent infection by interfering with virion adsorption and/or uncoating in a similar fashion as GPC-specific mAbs do. This antibody is capable of neutralizing Candid#1 virions but not pathogenic JUNV strains. This antibody can be used for the immunofluorescence staining of nucleoprotein obtained from Candid#1-infected cells and JUNV XJCl3 strain (PMID: 30061671).

Antibody first published in: Linero et al. Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein. Sci Rep. 2018; 8: 11451. PMID:30061671
Note on publication: Describes the generation of nanobodies against Junin virus nucleoprotein.

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