United Kingdom (UK)
Recombinant monoclonal antibody to Keratin, type II cytoskeletal 1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma AE1.
UniProt Accession Number of Target Protein: P04264
Alternative Name(s) of Target: CK-1; K1; KRT1; 67 kDa cytokeratin; Cytokeratin-1; Hair alpha protein; Keratin-1; Type-II keratin Kb1; CK10; CK14; CK15; CK16; CK19
Immunogen: The original antibody was raised by immunizing a mouse with human epidermal keratins.
Specificity: This antibody is specific for CK10, 14,15,16,19.
Application Notes: The original version of this antibody was used for immunohistochemistry on ectopic thyroid tissue (Ihtiyar et al., 2003; PMID:14513329), on sentinel lymph node tissue (Atinkaya et al., 2005; PMID:16000990), on lymph nodes (Yagci et al., 2007; PMID:16721490), and on tissue from rats bearing mammary tumours (Esendagli et al., 2009; PMID:18987061). Further this antibody was used for a western blot on 2 cancer cell lysates (Favia et al., 2004; PMID:15252853), and on DE-E, DE-F and DE-SF cell line lysates (Chang et al., 2010; PMID:19748110).
Antibody first published in:
Ihtiyar et al. Ectopic thyroid in the gallbladder: report of a case Surg Today. 2003;33(10):777-80. PMID:14513329
Note on publication:
The original paper describes an unusual case of ectopic thyroid tissue found in the gallbladder wall of a 68-year-old man who underwent cholecystectomy for acute cholecystitis.