United Kingdom (UK)
Recombinant monoclonal antibody to Large envelope protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma PC283.
UniProt Accession Number of Target Protein: P03142; Q91C35
Alternative Name(s) of Target: S; LHB; L-HBsAg; Large S protein; L glycoprotein; Large surface protein; Major surface antigen; L-HBsAg
Immunogen: The original antibody was raised by immunizing a BALB/c mouse with the PS1 CT3TT peptide.
Specificity: This antibody is specific for the PS1 peptide (HQLDPAFGANSTNPD) of large envelope protein of the Hepatitis B virus.
Application Notes: This antibody was used for an ELISA on peptides from the hepatitis B surface proteins (Agarwal et al., 1996; PMID:8816380). The structure of the original version of this antibody was determined using X-ray crystallography (Nair et al., 2002; PMID:11859128, Nayak et al., 1998; PMID:9759871).
Antibody first published in:
Agarwal et al. B cell responses to a peptide epitope. I. The cellular basis for restricted recognition J Immunol. 1996 Oct 1;157(7):2779-88. PMID:8816380
Note on publication:
The original paper examined the primary humoral responses in BALB/c mice to a variety of peptide constructs containing a common 15-amino acid residue antigenic determinant (PS1) in conjunction with one or more Th cell epitopes.