Anti-Melanin [8C3]

Name: Anti-Melanin [8C3]
SKU: Ab02814
Availability: InStock

Description:

Recombinant monoclonal antibody to Melanin. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 8C3.

Clone Name:

8C3

Published Application(s):

immunotherapy, radioimmunotherapy, ELISA, IF, IHC

Published Species Reactivity:

Species independent

Products based on this clone:

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Ab02814-23.0 Anti-Melanin [8C3]
Species independent
Rabbit IgG
Purified
In Stock

Ab02814-1.1 Anti-Melanin [8C3]
Species independent
Mouse IgG1
Purified
In Stock

Alternative Name(s) of Target: CHEBI:89634
Immunogen: The original antibody was generated by immunizing female BALB/c mice with melanin particles extracted from Paracoccidioides brasiliensis L-DOPA-induced yeast cells suspended in a 1:1 (vol/vol) emulsion of incomplete Freund adjuvant.

Specificity: This antibody binds melanin. Melanin is a natural pigment found in most organisms is produced in a specialized group of cells called the melanocytes.

Application Notes: Paracoccidioides brasiliensis is the agent of the human systemic disease paracoccidioidomycosis. The binding characterization of this antibody towards melanin from various organisms was done using ELISA. This antibody was also used in the immunofluorescence analysis of P. brasiliensis melanized yeast cells (with l-DOPA induction) and wild-type conidia (PMID: 21813659). 213Bismuth and 177Lutetium labelled humanized 8C3 antibody was used in the radioimmunotherapy (RIT) of experimental B16-F10 melanoma (PMID: 31323785). It was demonstrated that a combination of humanized anti-melanin antibody conjugated to 213Bismuth and anti-PD-1 ICB reduced tumor growth and increased survival in the Cloudman S91 murine melanoma DBA/2 mouse model (PMID: 31991626). Male Cloudman S91-bearing DBA/2 mice when treated intraperitoneally with a combination of anti-PD-1 alone or low-dose humanized anti-melanin antibody conjugated to177Lutetium RIT alone resulted in modest tumor reduction, while their combination significantly reduced tumor growth and increased survival, suggesting synergy (PMID: 33218169).

Antibody first published in: Urán et al. Detection of antibodies against Paracoccidioides brasiliensis melanin in in vitro and in vivo studies during infection Clin Vaccine Immunol. 2011 Oct;18(10):1680-8. PMID:21813659
Note on publication: Describes the generation and characterization of antibodies towards melanin particles from P. brasiliensis.

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