Anti-IgE [mAbA9]

Name: Anti-IgE [mAbA9]
SKU: Ab01158
Availability: InStock

Description:

Recombinant monoclonal antibody to IgE. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma mAbA9.

Clone Name:

mAbA9

Published Application(s):

Blocking, ELISA, FC

Published Species Reactivity:

Mouse

Products based on this clone:

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Ab01158-1.1 Anti-IgE [mAbA9]
Mouse
Mouse IgG1
Purified
Ships in 4-5 weeks

Ab01158-23.0 Anti-IgE [mAbA9]
Mouse
Rabbit IgG
Purified
Ships in 4-5 weeks

Alternative Name(s) of Target: mIgE; mouse Immunoglobulin E
Immunogen: This antibody was raised by immunising ΔM1M2 BALB/c mice, which cannot express membrane-bound IgE due to the lack of the IgE-transmembrane and IgE-cytoplasmic domains, with the extracellular membrane-proximal domain of mouse membrane IgE (EMPD) conjugated

Specificity: This antibody is specific for the extracellular membrane-proximal domain (EMPD) of murine membrane-bound IgE. As this 19-amino acid long EMPD is isotype-specific, this antibody does not cross-react with soluble mouse IgE.

Application Notes: This antibody binds to the extracellular membrane-proximal domain (EMPD) of mouse membrane-bound IgE with high specificity and affinity, as confirmed in ELISA analysis and FC analysis (Feichtner et al, 2008). In mice immunised with recombinant Bet v1a, the major birch pollen allergen, subsequent passive immunization with this antibody leads to a block of newly synthesized specific IgEs, and reduces serum Bet v1a-specific IgE titers (Feichtner et al, 2008). In vitro, this antibody induces receptor-mediated apoptosis in B cells expressing membrane-bound IgE (Feichtner et al, 2008).

Antibody first published in: Feichtner et al. Targeting the extracellular membrane-proximal domain of membrane-bound IgE by passive immunization blocks IgE synthesis in vivo. J Immunol. 2008 Apr 15;180(8):5499-505. PMID:18390733
Note on publication: Describes the original generation of this antibody, and its characterisation in ELISA and FC analysis.

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