United Kingdom (UK)
Recombinant monoclonal antibody to Neuraminidase. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma NC10.
UniProt Accession Number of Target Protein: P03472
Alternative Name(s) of Target: NA; 3.2.1.18; scFv(5); scFv(15)
Immunogen: The original antibody was raised by immunizing a BALB/c mouse with NA protein.
Specificity: This antibody is specific for Neuraminidase of influenza virus A.
Application Notes: The original version of this antibody was used for an ELISA on N9 Neuraminidase crystals (Webster et al., 1987; PMID:3612957), and on NA protein (McKimm-Berschkin et al., 1996; PMID:8918554, McKimm-Berschkin et al., 1998; PMID:9499107). The structure of a scFv version of this antibody was determined using x-ray crystallography (Malby et al., 1998; PMID:9642070).
Antibody first published in:
Webster et al. Antigenic Structure and Variation in an Influenza Virus N9 Neuraminidase J Virol. 1987 Sep;61(9):2910-6. PMID:3612957
Note on publication:
The original paper describes the properties of NC-41 and other monoclonal antibodies to N9 NA and the properties of variants selected with these antibodies.