Anti-PDL1 [14-02-3]

Description:

Recombinant monoclonal antibody to PDL1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the alpaca peripheral blood lymphocytes 14-02-3.

Clone Name:

14-02-3

Published Application(s):

Published Species Reactivity:

Human

UniProt Accession Number of Target Protein: Q9NZQ7

Alternative Name(s) of Target: CD274; PD-L1; B7-H1; B7H1; B7 homolog 1; hPD-L1; PDCD1L1; PDCD1LG1; PDCD1 ligand 1; Programmed cell death 1 ligand 1; Programmed death ligand 1; HZ-K-Yr-13 & 14-02-3
Immunogen: The original antibody was generated by immunizing 2 alpacas with human PDL1 antigen in Freund's adjuvant. The peripheral blood of the alpaca was taken to generate a yeast display nanobody library and the particular clone was isolated by screening the library against human PDL1.

Specificity: This antibody binds human PDL1. PD-L1 is highly expressed in many human tumors. PD-L1 exerts an immune suppressive signal through binding to PD-1 and B7.1, and tumor expression of PD-L1 can mediate cancer immune evasion. Blocking this pathway, therefore provides a rationale for cancer immunotherapy.

Application Notes: This antibody binds human PD-L1 with a binding affinity of Kd= 0.22 nM. This antibody in combination with an anti-PDL2 antibody HZ-D-Na-96-1 was used in the generation of a bispecific antibody targeting human PDL1 and PDL2 simultaneously. The resulting bispecific antibody was capable of blocking binding of PD-L2/PD-L1 to PD-1 and also block PDL1/PDL2/PD1/luc signaling pathway (WO2021197358).

Antibody first published in: PMID:

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