Anti-PDL2 [HZ-D-Na-96-1]

Description:

Recombinant monoclonal antibody to PDL2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the alpaca peripheral blood lymphocytes HZ-D-Na-96-1.

Clone Name:

HZ-D-Na-96-1

Published Application(s):

Block, FC

Published Species Reactivity:

Human

UniProt Accession Number of Target Protein: Q9BQ51

Alternative Name(s) of Target: CD273; PD-L2; PD L2; PDCD1LG2; PDCD1L2; B7DC; B7-DC; PD-1 ligand 2; PDCD1 ligand 2; PDCD1 ligand 2; Programmed cell death 1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC
Immunogen: The original antibody was generated by immunizing 2 alpacas with human PDL2 antigen in Freund's adjuvant. The peripheral blood of the alpaca was taken to generate a yeast display nanobody library and the particular clone was isolated by screening the library against human PDL2. Later on the single domain antibody was humanized using framework grafting method.

Specificity: This antibody binds human PD-L2, expressed on dendritic cells, IFN-gamma-treated monocytes, placental endothelium and medullary thymic epithelial cells. This protein is an immune checkpoint receptor ligand which plays a role in negative regulation of adaptive immune response. It is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner.

Application Notes: This antibody binds human PD-L2 with a binding affinity of Kd= 1.68 nM. The binding ability of this antibody towards human PD-L2 expressed on the surface of CHO cells was determined using flow cytometry. This antibody is capable of blocking the interaction between PDL2 and PD-1. This antibody in combination with an anti-PDL1 antibody 14-02-3 was used in the generation of a bispecific antibody targeting human PDL1 and PDL2 simultaneously. The resulting bispecific antibody was capable of blocking binding of PD-L2/PD-L1 to PD-1 and also block PDL1/PDL2/PD1/luc signaling pathway (WO2021197358).

Antibody first published in: PMID:

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