Anti-PGE2 [mAbPGE]

Description:

Recombinant monoclonal antibody to PGE2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma mAbPGE.

Clone Name:

mAbPGE

Published Application(s):

RIA, ELISA

Published Species Reactivity:

Species independent

Products based on this clone:

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Ab00484-1.1 Anti-PGE2 [mAbPGE]
Species independent
Mouse IgG1
Purified
In Stock

Ab00484-10.0 Anti-PGE2 [mAbPGE]
Species independent
Human IgG1
Purified
Ships in 4-5 weeks

Ab00484-10.6 Anti-PGE2 [mAbPGE]
Species independent
Human Fab fragment
His-Tagged
Purified
In Stock

Ab00484-10.7 Anti-PGE2 [mAbPGE]
Species independent
Human F(ab)2
AbFab2™ His-Tagged
Purified
Ships in 4-5 weeks

Ab00484-23.0 Anti-PGE2 [mAbPGE]
Species independent
Rabbit IgG
Purified
In Stock

Alternative Name(s) of Target: Prostaglandin E2
Immunogen: Human PGE2.

Application Notes: The antibody binds specifically to PGE2, a lipid compound synthesised from the oxidation of arachidonic acid by cyclooxygenases (COX-1 and COX-2), and from the action of prostaglandin E synthase on prostaglandin H2. PGE2 is an important inflammatory mediator and homeostatic factor that acts on the receptors EP1, EP2 and EP3, which are all members of the family of G-protein coupled receptors (GPCRs). The neutralisation of PGE2 by the use of monoclonal antibodies provides an alternative to the use of NSAIDs in the treatment of acute and chronic inflammatory diseases such as rheumatoid arthritis.

Antibody first published in: Shono F, Yokota K, Horie K, Yamamoto S, Yamashita K, Watanabe K, Miyazaki H. A heterologous enzyme immunoassay of prostaglandin E2 using a stable enzyme-labeled hapten mimic. Anal Biochem. 1988 Feb 1;168(2):284-91. PMID:3129960
Note on publication: Describes the development of an enzyme immunoassay for PGE2 utilising an anti-PGE2 antibody, in order to measure the amount of PGE2 present in human urine samples.