Anti-RNA-directed RNA polymerase L [SUDV MTase VHH]

Description:

Recombinant monoclonal antibody to RNA-directed RNA polymerase L. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display library SUDV MTase VHH.

Clone Name:

SUDV MTase VHH

Published Application(s):

crystallography, ELISA

Published Species Reactivity:

Sudan ebolavirus

UniProt Accession Number of Target Protein: Q5XX01

Alternative Name(s) of Target: L; Protein L, Large structural protein; Replicase; Transcriptase
Immunogen: The original antibody was raised by immunizing a llama with purified SUDV Mtase and then selecting from the created library through phage display.

Specificity: This antibody is specific for MTase (methyltransferase) domain of the genome polyprotein of the Sudan ebolavirus.

Application Notes: The structure of the original antibody was determined using cryo-EM and x-ray crystallography. This antibody was used for ELISA on SUDV Mtase. Further this antibody was used for immunoprecipitation on the Mtase protein (Valle et al., 2021; PMID:33503246).

Antibody first published in: Valle et al. First insights into the structural features of Ebola virus methyltransferase activities Nucleic Acids Res. 2021 Feb 22;49(3):1737-1748. PMID:33503246
Note on publication: The original paper identified structural determinants and key amino acids specifically involved in the internal adenosine-2'-O-methylation from cap-related methylations.

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