United Kingdom (UK)
Recombinant monoclonal antibody to ROR1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma M508.
UniProt Accession Number of Target Protein: Q01973
Alternative Name(s) of Target: NTRKR1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; R12
Immunogen: The original antibody was generated by immunizing wild-type mice with full-length extracellular portion of human ROR1 protein.
Specificity: This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes.
Application Notes: The binding reactivity of this antibody to full-length extracellular portion of human ROR1 protein and its truncated forms was done using ELISA. The binding reactivity and specificity of this antibody was comparable with another anti-ROR1 antibody R12. The mouse-human chimeric IgG1 version of this antibody binds human ROR1 with a binding affinity of Kd= 1.4 nM. This antibody could bind human ROR1 expressed on the surface of breast cancer cell line MDA-MB-231 in a flow cytometric assay. This antibody is recommended for detection of human ROR1 expressing tumor cells (CN114539411).
Antibody first published in: PMID: