Anti-SAR-55 ORF2 [HEV#31]

Description:

Recombinant monoclonal antibody to SAR-55 ORF2. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody HEV#31.

Clone Name:

HEV#31

Published Application(s):

neutralizing, SPR, WB, ELISA

Published Species Reactivity:

Hepatitis E virus

UniProt Accession Number of Target Protein: P33426

Alternative Name(s) of Target: HEV; Secreted protein ORF2; Protein ORF2; pORF2
Immunogen: A chimpanzee previously infected with specific viral pathogens was used as a source of bone marrow lymphocytes for the construction of a phage display library. The original antibody was isolated from this library.

Specificity: The antibody is specific for HEV. The antibody recognizes an epitope on the SAR-55 ORF2 protein. The antibody also recognises swine HEV.

Application Notes: The specificity of the original format of the antibody for SAR-55 ORF2 protein and swine HEV was confirmed by ELISA analysis (Kd= 0.8 and 1.3 nM respectively). The antibody recognized reduced, denatured HEV ORF2 protein by Western Blot. The antibody strongly precipitated the construct corresponding to aa112–607 of the ORF2 protein by radioimmunoprecipitation. The binding affinity of the antibody to SAR-55 ORF2 protein was measured by surface plasmon resonance (Kd= 4.5 nM). The original antibody was able to neutralize the SAR-55 strain of HEV, as determined by intravenous challenge of rhesus monkeys (US7148323B2).

Antibody first published in: PMID:

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