Anti-SEB [14G8]

Description:

Recombinant monoclonal antibody to SEB. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma 14G8.

Clone Name:

14G8

Published Application(s):

ELISA, WB, Inhibit

Published Species Reactivity:

Staphylococcus aureus

Products based on this clone:

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Ab02341-23.0 Anti-SEB [14G8]
Staphylococcus aureus
Rabbit IgG
Purified
In Stock

Ab02341-1.1 Anti-SEB [14G8]
Staphylococcus aureus
Mouse IgG1
Purified
In Stock

UniProt Accession Number of Target Protein: P01552

Alternative Name(s) of Target: Staphylococcal enterotoxin B; Enterotoxin type B; entB
Immunogen: The original antibody was generated by immunizing BALB/c mice with full-length staphylococcal enterotoxin B (SEB).

Specificity: This antibody binds a conformational epitope near the C terminal end of the Staphylococcal enterotoxin B. This antibody is suspected to interact with residues 135-R, 137-F, 186-Y, 188-K, 231-E, 233-Y, and 235, 236-T.

Application Notes: This antibody in combination with 6D3 and 20B1 can be used to detect Staphylococcal enterotoxin B (SEB) in a sample using capture ELISA. This antibody is capable of detecting SEB in a western blot assay but not staphylococcal enterotoxin A (SEA) or toxic shock syndrome toxin 1 (TSST-1). 14G8 demonstrated comparable level of inhibition of SEB incuded T cell-proliferation in human T-cells from a normal donor. 14G8 also caused inhibition of cytokine induction in treated T-cells as they produced less IFN-gamma and IL-2. It was reported that 14G8 alone did not provide any protection against SEB induced lethal shock (SEBILS) in BALB/c mice and HLA-DR3 transgenic mouse model. However, when used in combination with mAb 6D3 or 20B1 it showed better results (PMID: 21233204).

Antibody first published in: Varshney et al. Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin b-induced lethal shock. J Biol Chem. (2011); 286(11): 9737–9747. PMID:21233204
Note on publication: Describes the generation, characterization and epitope mapping of this antibody.

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