- {{heading}}
- Ab00109-1.1 Anti-Thy1.1 [OX7]
- Rat, Mouse
- Mouse IgG1
- Purified, Vivopure
- In Stock
- Ab00109-23.0 Anti-Thy1.1 [OX7]
- Rat, Mouse
- Rabbit IgG
- Purified
- In Stock
Recombinant monoclonal antibody to Thy1.1. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OX7.
UniProt Accession Number of Target Protein: P01830
Alternative Name(s) of Target: CD90; Thy-1 antigen; OX-7
Immunogen: Rat Thy- 1L+ antigen in complete Freund's adjuvant.
Specificity: Rat CD90, also known as Thy1.1, a GPI-anchored membrane protein containing a single V type Ig-like domain.
Application Notes: This antibody binds to Thy1.1, which is allelically restricted between different host strains. Administration of OX7 leads to anti-Thy1 Glomerulonephritis.
Antibody first published in:
Mason DW, Williams AF. The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem J. 1980 Apr 1;187(1):1-20. PMID:6967725
Note on publication:
Describes the generation of the antibody, shows it recognised Thy1.1 (Thy-1) by immuno-blotting of cell lines including thymocytes, neuronal cells, stem cells, immature B cells and connective tissues.
Flow-cytometry of thymocytes from two different mouse strains Thymocytes from FVB/N, BALB/c and their F1 progeny were stained with OX7 (anti-Thy1.1, Ab00109-1.1), IBL-1 (anti-Thy1.2) and KT-3 (anti-CD3). BALB/c express Thy1.1, whilst FVB/N express Thy1.2 – which is reflected in the specific antibody staining. Their F1 progeny however are positive for both markers, which again is clearly shown by the antibody staining.