Anti-TLR3 [132-D4]

Description:

Recombinant monoclonal antibody to TLR3. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody 132-D4.

Clone Name:

132-D4

Published Application(s):

NTRL, ELISA

Published Species Reactivity:

Mouse

UniProt Accession Number of Target Protein: Q99MB1

Alternative Name(s) of Target: Toll-like receptor 3; CD283
Immunogen: The original antibody was generated by immunizing llamas with a cocktail of murine and human Toll-like receptors (TLRs) that contained recombinant human TLR4/MD2, recombinant human TLR3, recombinant murine TLR3, and recombinant murine TLR2/Fc chimera. Peripheral blood mononuclear cells were isolated from the animals' blood for the construction of a phage display library, and the library was panned against the TLRs used for immunization.

Specificity: This antibody is specific for mouse TLR3.

Application Notes: The binding specificity of the original version of this antibody (VHH) was tested using ELISA. In a cell-based neutralizing assay with mTLR3-overexpressing HEK cells, an antagonistic effect was observed, as measured by NFκB expression after cell lysis compared to the control group (WO2009138494A2).

Antibody first published in: PMID:

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