Anti-toxin A [A20.1]

Description:

Recombinant monoclonal antibody to toxin A. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody A20.1.

Clone Name:

A20.1

Published Application(s):

BLI, neutralizing, SPR, ELISA

Published Species Reactivity:

Clostridium difficile

UniProt Accession Number of Target Protein: P16154

Alternative Name(s) of Target: TcdA; EC:3.4.22
Immunogen: The original antibody was generated by immunizing a llama with recombinant RBD fragments TcdA-RBD-f1 and TcdB-RBD-f1, followed by phage display library construction and panning against TcdA-RBD-f1.

Specificity: The antibody is specific for toxin A of Clostridium difficile. It recognises a conformational epitope on native C. difficile toxin.

Application Notes: The specificity of the original format of the antibody to TcdA was confirmed by ELISA analysis. The binding affinity of the original format of the antibody was measured by surface plasmon resonance (Kd= 2 nM). Human lung fibroblast (HLF) cytotoxicity assay was used to determine whether the original format of the antibody could neutralize TcdA-induced HLF cell rounding. The antibody showed neutralizing activity to TcdA (US9771416B2).

Antibody first published in: PMID:

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