Anti-VP1 protein [NEG447A]

Name: Anti-VP1 protein [NEG447A]
SKU: Ab03118
Availability: InStock

Description:

Recombinant monoclonal antibody to VP1 protein. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the synthetic clone NEG447A.

Clone Name:

NEG447A

Published Application(s):

ELISA

Published Species Reactivity:

BK virus, Human polyomavirus 1

Products based on this clone:

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Ab03118-23.0 Anti-VP1 protein [NEG447A]
BK virus, Human polyomavirus 1
Rabbit IgG
Purified
In Stock

Ab03118-10.0 Anti-VP1 protein [NEG447A]
BK virus, Human polyomavirus 1
Human IgG1
Purified
Ships in 4-5 weeks

Ab03118-15.0 Anti-VP1 protein [NEG447A]
BK virus, Human polyomavirus 1
Human IgM
Purified
Ships in 4-5 weeks

Ab03118-1.1 Anti-VP1 protein [NEG447A]
BK virus, Human polyomavirus 1
Mouse IgG1
Purified
In Stock

UniProt Accession Number of Target Protein: P03088

Alternative Name(s) of Target: BKV; BKPyV; Major capsid protein VP1; Major structural protein VP1; BK polyomavirus
Immunogen: The original antibody was generated synthetically by introducing point mutations in the germline sequence of the parental clone P165E2.

Specificity: This antibody binds the VP1 protein of the BK virus (Human polyomavirus 1). Polyomaviruses are icosahedral, non-enveloped, double-stranded DNA viruses. They measure 40-45 nm in diameter and are comprised of 88% protein and 12% DNA. Infection with the human polyomavirus BK (BKV) is essentially ubiquitous, with estimates ranging between 80 and 90% of the population globally infected. Primary infection most often occurs during childhood (i.e., before age 10) and results in either a mild, non-specific, self-limited illness or no symptoms at all.

Application Notes: This clone can be used for the detection of BK virus in a sample via ELISA. This clone is derived from P165E2 and has ~3-fold greater affinity and ~8-fold more potent activity (EC90) on serotype II, ~10-fold greater affinity for serotype IV than the parental clone. The parental clone P165E2, binds all four serotypes of BKV but cannot recognize denatured VP1 in western blot. Binding of the antibody is affected with mutations F66A, I145A, K69A and E82A in the VP1 protein (US9862760).

Antibody first published in: PMID:

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