Antibody Expression Services

 

Learn how we’ve optimized antibody expression and purification in a presentation from our CSO.

View the 145 antibody formats we’ve manufactured to date.

Our HEXpress™ and CHXpress™ antibody expression platforms rapidly produce high-quality, animal-free recombinant antibodies at milligram-to-gram scale in HEK or CHO cells. Our serum-free mammalian transient expression system offers a faster, more affordable alternative to stable cell line generation, and we’ve used it to manufacture recombinant antibodies in any species, isotype or format with high purity and low endotoxin levels.

Depending on your antibody expression needs, we can provide a reliable outsourcing solution for antibody production, or a true consultative partnership for developing the best possible engineered antibody. All production occurs at our ISO 9001:2015-certified manufacturing facility, which enables high-throughput capacity and the ability to scale up to multi-gram quantities within weeks.

We have experience manufacturing antibodies for clients worldwide, including pharmaceutical and biotechnology companies, diagnostic assay developers and academic researchers. In 2020, we produced nearly 4,000 different recombinant antibodies, making 180 grams of protein in total and expanding our all-recombinant reagents catalog to more than 8,500 antibodies. As illustrated by our Periodic Table of Antibodies, we’ve manufactured more than 140 different antibody formats to date, including multispecific antibodies, fragments and Fc fusion proteins.

Our antibody expression services are all royalty-free and customizable to your needs. We can start from an electronic antibody sequence, hybridoma cell line or purified antibody protein. In addition, your project will be supported by scientific staff with deep expertise in antibody development, a dedicated project manager, and a global customer service team across North America, Europe and Asia.

Read about all our different antibody expression services below. To learn more, contact us or fill out the form to start a discussion about your project.

 

We produce IgG antibodies in any species or subtype (including chimeric antibodies), at quantities ranging from 1 mg to 2 g. HEXpress™ and CHXpress™ are available in two levels of production, Silver and Gold, which both provide highly purified antibody suitable for in vitro and in vivo needs. The Gold service offers stricter control on monomer purity and endotoxin levels for therapeutic antibody development.

 

We specialize in antibody engineering, and we’ve successfully manufactured antibodies in more than 140 different formats, including various isotypes, fragments and multispecifics. IgXpress™, our engineered antibody production, typically starts with a milligram-scale pilot run to determine expression levels before moving onto larger-scale production. We can provide free antibody engineering consultation to help clients develop the best antibody candidate.

 

Our FleXpress™ service allows clients to rapidly express large numbers of IgG antibodies at 80 ml scale using our proven recombinant antibody technology. This service is particularly useful for early-stage pilot studies on a group of therapeutic antibody candidates, as well as converting a monoclonal antibody portfolio from hybridomas to recombinant production.

Contact Us About Your Antibody Expression Project

Fill out the form below to start a conversation about your antibody expression needs. A sales representative will be in touch shortly to discuss details, review pricing and answer any questions.
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