VivopureX™ Antibodies for Improved In Vivo Research

VivopureX™ antibodies are recombinant mouse antibodies ideal for in vivo research in mouse models. The collection consists of popular antibody clones, many originally obtained from rats or hamsters, which Absolute Antibody has engineered into mouse-anti-mouse recombinant versions to improve research results. These species-matched chimeric antibodies consist of a clone’s original antigen-binding variable domain with a mouse constant domain.

Our VivopureX™ recombinant mouse antibodies offer many advantages compared to the original antibody format, including:

  • Reduced immunogenicity: no neutralizing antibodies are induced in the host organism, meaning the antibody works for longer and cohorts respond more consistently.
  • Tailored effector function: antibody formats have been engineered to suit their most popular application. (Increased Fc receptor binding increases depleting potential, while reduced Fc receptor binding reduces side effects in blocking.)
  • Increased potency: less antibody is required to achieve the same response in mouse models.
  • Batch-to-batch reproducibility: recombinant production ensures the highest possible reproducibility, and guarantees high purity and low endotoxins (<0.5 EU/mg).

Mean tumor sizes in animals treated with PD-1 mouse IgG2a Fc Silent™ antibody based on clone RMP1-14 (Ab00813-2.3) are significantly smaller than in animals treated with the traditional rat IgG2a antibody (Ab00813-7.1). Download our research poster to learn more.

Our data illustrate how VivopureX™ mouse antibodies provide increased long-term efficacy, potency and consistency compared to the original rat antibodies. In the figure to the left, our recombinant mouse PD-1 antibody based on the widely used clone RMP1-14 reduced tumor size in a mouse model more effectively than the original rat version. Download our research poster on the engineered PD-1 antibody to learn more.

Looking for another example? One of our customers used a species-matched mouse-anti-mouse antibody to deplete CD8+ T-cells in mice more completely and for longer than the original rat antibody. Read the full case study here.

The VivopureX™ antibody collection includes a selection of our most exciting mouse-anti-mouse antibodies, now available at competitively priced bulk prices. All are available in discounted bulk sizes ranging from 1 mg to 100 mg, as well as our standard 200 µg size.

We’ll continue to add new antibodies to the list below, so check back for updates! Contact us with questions, to receive a quote, or to ask if another antibody could be made available in a mouse-anti-mouse format in bulk for in vivo research.

Antibody Name [Clone]Engineered FormatTop Application
Available Bulk Sizes
Anti-OX40/CD134 [OX86]
Mouse IgG2a
Agonism
1 mg, 10 mg, 25 mg, 100 mg
Anti-PD-1 [RMP1-14]
Mouse IgG2a Fc Silent™
Blocking
1 mg, 10 mg, 25 mg, 100 mg
Anti-CTLA-4 [9D9]
Mouse IgG2a

Blocking, Treg depletion
1 mg, 10 mg, 25 mg, 100 mg
Anti-CTLA-4 [9D9]
Mouse IgG2a Fc Silent™
Blocking, peripheral Treg expansion
1 mg, 10 mg, 25 mg, 100 mg
Anti-GITR [DTA-1]
Mouse IgG2a
Agonism
1 mg, 10 mg, 25 mg, 100 mg
Anti-CD25 [PC-61.5.3]
Mouse IgG2a
Depletion
1 mg, 10 mg, 25 mg, 100 mg
Anti-TIGIT [1B4]
Mouse IgG1
Blocking
1 mg, 10 mg, 25 mg, 100 mg
Anti-Lag3 [C9B7W]Mouse IgG2a Fc Silent™Blocking
1 mg, 10 mg, 25 mg, 100 mg
Anti-CD96 [6A6]
Mouse IgG2a Fc Silent™
Blocking
1 mg, 10 mg, 25 mg, 100 mg
Anti-IL-10R [1B1.3a]
Mouse IgG2a Fc Silent™
Blocking
1 mg, 10 mg, 25 mg, 100 mg
Anti-B7-H4 [7A1-6]Mouse IgG2a Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-BTLA [HMBT-6B2]
Mouse IgG2a Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-Tim-4 [3A1]
Mouse IgG2a Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-Tim-4 [5G3]Mouse IgG2a Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-TIM-2 [RMT2-14]Mouse IgG2a Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-Tim-1 [3B3]Mouse IgG1Agonism1 mg, 10 mg, 25 mg, 100 mg
Anti-Tim-3 [2C12]Mouse IgG2a Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-CD115/M-CSFR [AFS98]Mouse IgG2aDepletion1 mg, 10 mg, 25 mg, 100 mg
Anti-PD-L1 [10F.9G2]Mouse IgG2b Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-IFN-gamma receptor 1 [GR20]Mouse IgG2b Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-VISTA [13F3]Mouse IgG2b Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg
Anti-CD20 [18B12]Mouse IgG2aDepletion10 mg, 25 mg, 100 mg
Anti-CD4 epitope A [YTS 177.9]Mouse IgG2aDepletion10 mg, 25 mg, 100 mg
Anti-CD4 epitope A [YTS 191.1]Mouse IgG2aDepletion10 mg, 25 mg, 100 mg
Anti-CD8 alpha/Lyt-2 [YTS 169.4]Mouse IgG2aDepletion10 mg, 25 mg, 100 mg
Anti-Ly6G [1A8]Mouse IgG2aDepletion10 mg, 25 mg, 100 mg
Anti-CD200R [OX131]Mouse IgG1 Fc Silent™
Blocking10 mg, 25 mg, 100 mg
Anti-PD-L2 [TY25]Mouse IgG2a Fc Silent™
Blocking1 mg, 10 mg, 25 mg, 100 mg